From Structural Studies to HCV Vaccine Design
نویسندگان
چکیده
منابع مشابه
HCV reinfection studies and the door to vaccine development.
Two decades have passed since the discovery of hepatitis C virus (HCV) in 1989 [1]. Despite a massively expanded understanding of the virus and rapidly improving treatments, there is still no effective vaccine to prevent new HCV infections. A central question in HCV vaccine development is whether long-lasting, sustained protective immunity against HCV can be achieved. Multiple chimpanzee and hu...
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Hepatitis C virus (HCV) is an important global health concern with approximately 185 million people infected [1]. HCV infection most often leads to chronic infection with few early symptoms, but chronically infected individuals can develop liver cirrhosis and hepatocellular carcinoma. Genome-wide association studies in humans have identified innate associated genes and HLA class II as important...
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The exploitation of DNA for the production of nanoscale architectures presents a young yet paradigm breaking approach, which addresses many of the barriers to the self-assembly of small molecules into highly-ordered nanostructures via construct addressability. There are two major methods to construct DNA nanostructures, and in the current review we will discuss the principles and some examples ...
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Prevention of hepatitis C virus (HCV) infection by vaccination has been a priority since discovery of the virus and the need has not diminished over the past 25 years. Infection rates are increasing in developed countries because of intravenous drug use. Reducing transmission will be difficult without a vaccine to prevent persistence of primary infections, and also secondary infections that may...
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ژورنال
عنوان ژورنال: Viruses
سال: 2021
ISSN: 1999-4915
DOI: 10.3390/v13050833